Hepatocyte Markers




Hepatocytes make up 70-80% of the cytoplasmic mass of the liver. These cells are involved in protein synthesis, protein storage and transformation of carbohydrates, synthesis of cholesterol, bile salts and phospholipids, and detoxification, modification and excretion of exogenous and endogenous substances. The hepatocyte also initiates the formation and secretion of bile.





alpha-Fetoprotein (AFP)


Annexin I and Annexin II

  • useful markers for detecting not only actively proliferating hepatocytes but also hepatocytes in preproliferative and postproliferative stages. PMID: 7519163

anti-liver-kidney microsome antibody

  • can be considered as a marker for endoplasmic reticulum in rat hepatocytes. PMID: 3552922

C-reactive protein (CRP)

  • a prototype acute phase protein which has been known to be synthesized in hepatocytes. PMID: 12637157

Hepatocyte antigen (Hep)

Hepatocyte Paraffin 1 (Hep Par 1)

Leucine Aminopeptidase (LAP)

Prospero-related homeobox 1 (Prox1)

  • a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells". PMID: 16770575


  • a marker for hepatocyte differentiation/dedifferentiation processes and tumor formation. PMID: 16959394

Tyrosine Aminotransferase

Tryptophan Oxygenase


  • a common marker of both hepatocyte and endothelial progenitors. PMID: 15607745