Nasopharyngeal Carcinoma (NPC) Markers

 

 

 

Nasopharyngeal Carcinoma (NPC)

 

 

 

Bmi-1

  • plays an important role in the development and progression of nasopharyngeal carcinoma, and that Bmi-1 is a valuable marker for assessing the prognosis of nasopharyngeal carcinoma patients. PMID: 16778197

CENP-H protein

  • a valuable marker of NPC progression. High CENP-H expression is associated with poor overall survival in NPC patients. PMID: 17255272

CYFRA 21-1

Cytokeratin 19 (CK-19

  • the presence of CK-19 mRNA in the peripheral blood may be a potential marker of micrometastasis for nasopharyngeal carcinoma (NPC). PMID: 11802221

EBERs

  • can be used as a sensitive marker to identify nasopharyngeal carcinoma (NPC) cells at various metastatic sites by techniques of in situ hybridization, and that demonstration of EBERs in lesions of undifferentiated histology may be useful as a diagnostic adjunct for NPC presenting as metastatic cancer of unknown origin. PMID: 8646721

EBV DNA

  • Circulating EBV DNA as a tumor marker for nasopharyngeal carcinoma. PMID: 12450734

EBV-specific DNase

  • may be a useful marker for detection of patients with NPC, and they imply that individuals having high levels of antibody to EBV DNase activity may have an increased risk of development of NPC. PMID: 2542436

  • Epstein-Barr virus-specific DNase is a marker for the early detection of nasopharyngeal carcinoma. PMID: 2995572

IgA/VCA

  • is of marginal significance in the monitoring of nasopharyngeal carcinoma (NPC) patients during follow-up. PMID: 7926060

MB-1

  • may be useful as a tumor marker of nasopharyngeal carcinoma (NPC). PMID: 7510513

TK (thymidine kinase)

  • the TK ELISA presents a strong predictor of NPC and, in its refined form, has improved pickup rates. PMID: 11267982

TPS (Tissue polypeptide specific antigen)

  • may have a potential clinical role as a valuable tumor marker for nasopharyngeal carcinoma (NPC). PMID: 11205197

  • serum/plasma EBV DNA constitutes a reliable tumor marker prior to, during, and after treatment of NPC. PMID: 10741733

VCA IgA

  • specific VCA IgA antibody may serve as a better marker for screening nasopharyngeal carcinoma (NPC) than EBV DNA detected by PCR. PMID: 11316043