Alveolar Cell Markers




Pneumonocyte; any cell of the walls of the pulmonary alveoli; often restricted to the cells of the alveolar epithelium (squamous alveolar cells and great alveolar cells) and alveolar phagocytes.


See also Epithelial Cell Markers




Alkaline phosphatase

  • a marker of alveolar type II cell differentiation. PMID: 2462386


  • cytokeratin synthesis is a marker of type 2 cell differentiation in adult and maturing fetal lung alveolar cells. PMID: 2458290


  • an integral apical membrane protein of the human alveolar type I cell. PMID: 10424584


  • new type I alveolar epithelial cell marker of the rat. PMID: 8720458

MPA (Maclura pomifera lectin)

  • cell-specific marker for alveolar epithelium in fetal rat lung. PMID: 2189457

MPA binding glycoproteins (MPA-gp330)

  • has an apparent molecular weight of 330 kD and is analogous to a similar membrane glycoprotein found in rat and rabbit type 2 cells. PMID: 2733026

  • a candidate for a differentiation marker for alveolar type II cells in adult rat lung. Preliminary data suggests that this 185 kd MPA binding glycoprotein is not found in ATI cells. PMID: 2916648

P2X7 and GABRP

  • identified in this study could be used as potential AEC I and AEC II markers for studying lung epithelial cell biology and monitoring lung injury. PMID: 15184050


RAGE (receptor for advanced glycation endproducts)

  • the highly selective differentiation marker of human alveolar epithelial type I cells. PMID: 16315007

  • a marker for basolateral membranes of well-differentiated ATI cells. ATI cells require some signal provided by the in vivo environment to express RAGE. PMID: 15009093


  • an alveolar type I cell-specific protein, has been shown to be an accurate marker of alveolar epithelial damage. PMID: 10712353

  • a differentiation marker of type I alveolar epithelial cells. PMID: 9761764

SBA (Soybean agglutinin)

  • a marker of type I alveolar epithelial cells and alveolar macrophages in mini pigs. PMID: 7518176

SPA (surfactant protein A, SP-A)

  • alveolar type II cell markers in acinar adenocarcinomas and adenoid cystic carcinomas arising from segmental bronchi. PMID: 8386445

SPB (surfactant protein B, SP-B)

  • SPB promoter activity is restricted in the adult to type II alveolar epithelial cells and bronchial epithelial cells. PMID: 11238857

  • SPB gene transcription is restricted to bronchiolar and alveolar epithelium. PMID: 7958446

  • a 79-amino-acid hydrophobic protein that enhances the surface active properties of pulmonary surfactant. SPB is expressed in nonciliated bronchiolar and alveolar type II cells of the respiratory epithelium, and its expression increases markedly late in gestation. PMID: 8496176

SPC (surfactant protein C, SP-C)