Apud Cell Markers




A group of endocrine cells derived from primitive cell types in the neural crest and found throughout the body. The apud cells are capable of amine precursor uptake and decarboxylation and of synthesizing and secreting polypeptide hormones including serotonin, epinephrine, dopamine, neurotensin, and norepinephrine.




Neuron-specific enolase (NSE)

  • immunoreactivity correlated closely with serotonin immunoreactivity, is a marker of Apud cells. PMID: 2409946

  • neuron-specific enolase (NSE) level is elevated in neurons and in numerous cells of the APUD system. PMID: 1347764

  • In normal conditions, neuron-specific enolase (NSE) is histochemically demonstrable only in neurons and cells of the amine precursor uptake and decarboxylation (APUD) system. PMID: 6547318

  • The presence of neuron-specific enolase in both mucosal APUD cells and autonomic nerves has established this newly discovered neuronal enzyme as a useful marker for the entire neuroendocrine system of the lung and its derivative neoplasms. PMID: 6188607

  • a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue, and was later shown to be present in APUD (amine precursor uptake and decarboxylation) cells and neurons of the diffuse neuroendocrine system but not in other peripheral cells. PMID: 6111674